The prognostic value of the pretreatment serum albumin to globulin ratio for predicting adverse pathology in patients undergoing radical prostatectomy for prostate cancer
Investigative and Clinical Urology 2021³â 62±Ç 5È£ p.545 ~ p.552
Á¤Àç¿í(Chung Jae-Wook) - Kyungpook National University School of Medicine Department of Urology
ÇÏÀ±¼®(Ha Yun-Sok) - Kyungpook National University School of Medicine Department of Urology
±è»ó¿ø(Kim Sang-Won) - Kyungpook National University School of Medicine Department of Urology
¹Ú½Âö(Park Seung-Chol) - Wonkwang University School of Medicine Department of Urology
°Åÿø(Kang Taek-Won) - Chonnam National University Medical School Chonnam National University Hospital Department of Urology
Á¤¿µ¹ü(Jeong Young-Beom) - Jeonbuk National University Medical School Department of Urology
¹Ú¼º¿ì(Park Sung-Woo) - Pusan National University Yangsan Hospital Department of Urology
¹ÚÁø¼º(Park Jin-Sung) - Eulji University School of Medicine Eulji University Hospital Department of Urology
À¯Àº»ó(Yoo Eun-Sang) - Kyungpook National University School of Medicine Department of Urology
±ÇűÕ(Kwon Tae-Gyun) - Kyungpook National University School of Medicine Department of Urology
¼¼ºÇÊ(Seo Sung-Pil) - Chungbuk National University College of Medicine Department of Urology
°È£¿ø(Kang Ho-Won) - Chungbuk National University College of Medicine Department of Urology
±è¿øÅÂ(Kim Won-Tae) - Chungbuk National University College of Medicine Department of Urology
±è¿ëÁØ(Kim Yong-June) - Chungbuk National University College of Medicine Department of Urology
ÀÌ»óö(Lee Sang-Cheol) - Chungbuk National University College of Medicine Department of Urology
±è¿øÀç(Kim Wun-Jae) - Chungbuk National University College of Medicine Department of Urology
À±¼®Áß(Yun Seok-Joong) - Chungbuk National University College of Medicine Department of Urology
±èÅÂȯ(Kim Tae-Hwan) - Kyungpook National University School of Medicine Department of Urology
Abstract
Purpose: Few studies have demonstrated the clinical significance of pretreatment serum albumin and globulin in prostate cancer (PCa). This study evaluated the association between the pretreatment albumin to globulin ratio (AGR) and clinicopathologic characteristics of nonmetastatic PCa in a large multicenter setting in Korea.
Materials and Methods: This study involved 742 patients with nonmetastatic PCa who underwent radical prostatectomy (RP) in seven institutions between January 2011 and December 2012. The AGR was calculated as follows: albumin/(total protein?albumin). Patients were divided into low and high AGR groups by a cutoff value from a receiver operating characteristic curve analysis.
Results: The best cutoff for the AGR was set at 1.53. The area under the curve of the AGR was 0.624 (95% confidence interval, 0.557?0.671; p<0.001). Patients who had a lower pretreatment AGR (<1.53) were identified as the low AGR group (n=398, 53.6%) and the remaining patients as the high AGR group (n=344, 46.4%). Preoperative AGR was significantly lower in patients with non-organ-confined disease (¡ÃpT3) than in those with organ-confined disease (¡ÂpT2) (p<0.001). The low AGR group had higher aggressive pathologic Gleason scores (pGS) (¡Ã8) than did the high AGR group (p=0.016). Furthermore, the AGR was an independent prognostic factor for high pGS (¡Ã8) and non-organ-confined disease (¡ÃpT3), according to multivariate logistic regression analysis.
Conclusions: A low AGR was closely associated with nonconfined disease (¡ÃpT3) and high pGS (¡Ã8). AGR can be a useful serological marker for predicting adverse pathology in patients with nonmetastatic PCa who undergo RP.
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Albumin, Globulin, Pathology, Prostate cancer, Prostatectomy
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Ths study results suggest that the AGR may be a useful serological marker for further characterization of adverse pathology in patients with nonmetastatic PCa who undergo RP.